Article
Transgenic mice transcribing the human H1 zero histone gene exhibit a normal phenotype.
European journal of biochemistry - 1 Apr 1997
Tönjes R R, Paul D, Doenecke D
Abstract excerpt
The linker histone H1degree accumulates in terminally differentiating cells and replaces other members of the H1 histone family, even in the absence of cell division. To study the role of H1degree in vivo, we have created two lines of transgenic mice with either the human H1degree promoter (HH minigene) or the mouse metallothionein T promoter (MH minigene) upstream of the human H1degree gene. Mice bearing the...
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