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Article

Propagation of the human polyomavirus, JCV, in human neuroblastoma cell lines.

Virology - 17 Feb 1997

Shinohara T, Nagashima K, Major E O

Abstract excerpt

Susceptibility to infection by the human polyomavirus, JCV, is determined by intracellular mechanisms which control transcription and replication. Originally thought to propagate well only in human cells of oligodendroglial lineage, JCV has recently been shown to infect astrocytes, astrogliomas, and a neuroblastoma cell line. The data reported here describe two cell types that have been subcultured from a human...

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Identifiers

PMID: 9123834
DOI: 10.1006/viro.1996.8409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glial cells of the human developing brain and B cells of the immune system share a common DNA binding factor for recognition of the regulatory sequences of the human polyomavirus, JCVSemantic proximity Read ↗

The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brainSemantic proximity Read ↗

JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytesSemantic proximity Read ↗

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