Article
Identification of a committed T cell precursor population in adult human peripheral blood.
The Journal of experimental medicine - 3 Mar 1997
Bruno L, Res P, Dessing M, Cella M, Spits H
Abstract excerpt
Here, we report data concerning the discovery in adult human peripheral blood of a precursor cell population able to differentiate into CD4+CD3+ alpha beta + mature T cells. These cells, which represent 0.1-0.5% of total peripheral blood mononuclear cells (PBMC), express substantial levels of CD4...
Topics
- Adult
- Animals
- Antigens, CD
- Antigens, Differentiation
- Blood Circulation
- Cell Differentiation
- Flow Cytometry
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Hematopoietic Stem Cells
- Homeodomain Proteins
- Humans
- Male
- Mice
- Organ Culture Techniques
- Phenotype
- Polymerase Chain Reaction
- Proteins
- Receptors, Antigen, T-Cell, alpha-beta