Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3- lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood.

Abstract excerpt

Intestinal intraepithelial lymphocytes (IEL) were studied, after isolation in humans, for their surface antigens with a large variety of monoclonal antibodies. They show peculiar characteristics when compared with peripheral blood lymphocytes and intestinal lamina propria lymphocytes. Although a majority of human intraepithelial lymphocytes (IEL) express an alpha/beta type of T cell receptor (TcR), 13% express a...

Topics

• Antigens, CD
• Antigens, Differentiation, T-Lymphocyte
• CD3 Complex
• Flow Cytometry
• Frozen Sections
• Humans
• Immunohistochemistry
• Intestinal Mucosa
• Intestine, Small
• Phenotype