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Article

Transgenic mice carrying chimeric or mutated type III intermediate filament (IF) genes.

Cellular and molecular life sciences : CMLS - 1 Jan 1997

Bloemendal H, Raats J M, Pieper F R, Benedetti E L, Dunia I

Abstract excerpt

Mice carrying chimeric, truncated or mutated genes encoding intermediate filament (IF) proteins type III do not show any detectable severe pathology. However, upon (over)expression of the transgene in the eye lens all animals develop lens opacification (cataract). At the cellular level the loss of visual acuity is preceded by interference with the terminal differentiation of lens fibre cells, plasma membrane...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9117989
DOI: 10.1007/pl00000571
PMCID: PMC11147384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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