Article
Mice lacking vimentin develop and reproduce without an obvious phenotype.
Cell - 18 Nov 1994
Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C
Abstract excerpt
To address the biological role of vimentin in the context of the living organism, we have introduced a null mutation of the vimentin gene into the germ line of mice. Surprisingly, animals homozygous for this mutation developed and reproduced without an obvious phenotype. Immunoblotting, immunoflu...
Topics
- Animals
- Chimera
- Cytoskeleton
- Female
- Fluorescent Antibody Technique
- Genetic Vectors
- Genomic Library
- Heterozygote
- Humans
- Intermediate Filaments
- Male
- Mice
- Mice, Transgenic
- Microscopy, Immunoelectron
- Mutagenesis
- Mutation
- Organ Specificity
- Phenotype