Article
Mice lacking vimentin develop and reproduce without an obvious phenotype.
Cell - 18 Nov 1994
Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C
Abstract excerpt
To address the biological role of vimentin in the context of the living organism, we have introduced a null mutation of the vimentin gene into the germ line of mice. Surprisingly, animals homozygous for this mutation developed and reproduced without an obvious phenotype. Immunoblotting, immunofluorescence, and immunogold labeling analysis confirmed the absence of vimentin and of the corresponding filament...
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