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Article

Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997

Park H O, Bi E, Pringle J R, Herskowitz I

Abstract excerpt

Cells of budding yeast organize their cytoskeleton in a highly polarized manner during vegetative growth. Selection of a site for polarization requires a group of proteins including a Ras-like GTPase, Bud1, and its regulators. Another group of proteins, which includes a Rho-like GTPase (Cdc42), its guanine nucleotide exchange factor (Cdc24), and Bem1, is necessary for organization of the actin cytoskeleton and...

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Identifiers

PMID: 9114012
DOI: 10.1073/pnas.94.9.4463
PMCID: PMC20745

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Research trail→

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Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity.PMID 9114012Read ↗

A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization.Semantic proximity Read ↗

The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast.Semantic proximity Read ↗

Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site.Semantic proximity Read ↗

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast.Semantic proximity Read ↗

Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast.Semantic proximity Read ↗

A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity.Semantic proximity Read ↗

The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition.Semantic proximity Read ↗

Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1.Semantic proximity Read ↗

Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast.Semantic proximity Read ↗

The shared role of the Rsr1 GTPase and Gic1/Gic2 in Cdc42 polarization.Semantic proximity Read ↗

Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.Semantic proximity Read ↗

Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development.Semantic proximity Read ↗

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