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Article

A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity.

Science (New York, N.Y.) - 18 May 2001

Kang P J, Sanson A, Lee B, Park H O

Abstract excerpt

In both animal and yeast cells, signaling pathways involving small guanosine triphosphatases (GTPases) regulate polarized organization of the actin cytoskeleton. In the budding yeast Saccharomyces cerevisiae, the Ras-like GTPase Bud1/Rsr1 and its guanosine 5'-diphosphate (GDP)/guanosine 5'-triphosphate (GTP) exchange factor Bud5 are involved in the selection of a specific site for growth, thus determining cell...

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Identifiers

PMID: 11313501
DOI: 10.1126/science.1060360
PMCID: PMC4386611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity.PMID 11313501Read ↗

Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast.Semantic proximity Read ↗

Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site.Semantic proximity Read ↗

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast.Semantic proximity Read ↗

The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast.Semantic proximity Read ↗

Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1.Semantic proximity Read ↗

Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity.Semantic proximity Read ↗

A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization.Semantic proximity Read ↗

Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast.Semantic proximity Read ↗

Subcellular localization of Axl1, the cell type-specific regulator of polarity.Semantic proximity Read ↗

Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development.Semantic proximity Read ↗

Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.Semantic proximity Read ↗

Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

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