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Article

End of the line for "third-generation-pill" controversy?

Lancet (London, England) - 19 Apr 1997

Vandenbroucke J P, Rosendaal F R

Abstract excerpt

Through modification of an in vitro test for thrombosis formation, a Dutch research group has made three significant findings: 1) third-generation oral contraceptives (OCs) induce a resistance to the blood's natural anticoagulation system of a magnitude close to that induced by a mutation in coagulation factor V Leiden; 2) second-generation OCs show only part of the effect; and 3) in OC users heterozygous for the...

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Identifiers

PMID: 9113005
DOI: 10.1016/S0140-6736(05)63015-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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End of the line for "third-generation-pill" controversy?PMID 9113005Read ↗

[From pill to pill: oral contraception, venous thrombosis and coagulation disorders].Semantic proximity Read ↗

Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen.Semantic proximity Read ↗

Third generation oral contraceptives and heritable thrombophilia as risk factors of non-fatal venous thromboembolism.Semantic proximity Read ↗

Factor V Leiden: should all women be screened prior to commencing the contraceptive pill?Semantic proximity Read ↗

Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial.Semantic proximity Read ↗

APC resistance and third-generation oral contraceptives: Acquired resistance to activated protein C, oral contraceptives and the risk of thromboembolic disease.Semantic proximity Read ↗

[Public health economic evaluation of screening for APC resistance (Leiden mutation) in new oral contraceptive users].Semantic proximity Read ↗

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.Semantic proximity Read ↗

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