Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.

doi:10.1016/s0140-6736(94)90286-0

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Article

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.

Lancet (London, England) - 26 Nov 1994

Vandenbroucke J P, Koster T, Briët E, Reitsma P H, Bertina R M, Rosendaal F R

Abstract excerpt

We investigated whether the occurrence of venous thrombosis in young women who use oral contraceptives might be explained by the factor V Leiden mutation, which leads to resistance to activated protein C and enhances susceptibility to thrombosis. We compared 155 consecutive premenopausal women, a...

Topics

Adolescent
Adult
Case-Control Studies
Contraceptives, Oral
Factor V
Female
Heterozygote
Humans
Logistic Models
Middle Aged
Mutation
Netherlands
Protein C
Risk
Risk Factors
Thrombophlebitis

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