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Article

Molecular characterization of a dominantly inherited bleeding disorder with impaired platelet responses to thromboxane A2.

Polish journal of pharmacology - 1 Jan 2000

Okuma M, Hirata T, Ushikubi F, Kakizuka A, Narumiya S

Abstract excerpt

Thromboxane A2 (TXA2) is a major arachidonic acid metabolite of platelets and induces platelet functions by binding to specific receptors on the membrane. We have found patients with hemostatic defects due to impaired platelet responses to TXA2, and molecular characterization of the patients has been carried out. Platelets from these two unrelated patients showed impaired aggregation responses to TXA2 and its...

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PMID: 9112632

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