Article
TBXA2R gene variants associated with bleeding.
Platelets - 1 Nov 2018
Mundell Stuart James, Mumford Andrew
Abstract excerpt
Platelet activity is regulated by a number of surface expressed G protein-coupled receptors (GPCRs) including the α isoform of the thromboxane receptor (TPα receptor). With the advance of genomic technologies, there has been a substantial increase in the identification of naturally occurring rare GPCR variants including in the TBXA2R gene, which encodes the TPα receptor. The study of patients with naturally...
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