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Article

Differential pathogenesis of primary CCR5-using human immunodeficiency virus type 1 isolates in ex vivo human lymphoid tissue.

Journal of virology - 1 Sept 2005

Karlsson Ingrid, Grivel Jean-Charles, Chen Silvia Sihui, Karlsson Anders, Albert Jan, Fenyö Eva Maria, Margolis Leonid B

Abstract excerpt

In the course of human immunodeficiency virus (HIV) disease, CCR5-utilizing HIV type 1 (HIV-1) variants (R5), which typically transmit infection and dominate its early stages, persist in approximately half of the infected individuals (nonswitch virus patients), while in the other half (switch virus patients), viruses using CXCR4 (X4 or R5X4) emerge, leading to rapid disease progression. Here, we used a system of...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CXCR4 gene

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Share to Lymphocyte Depletion

Share to Receptors, CCR5

Source

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Identifiers

PMID: 16103166
DOI: 10.1128/JVI.79.17.11151-11160.2005
PMCID: PMC1193585

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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