Article
Impact of knockout mice in toxicology.
Critical reviews in toxicology - 1 Mar 1997
Ryffel B
Abstract excerpt
Knockout mice obtained by homologous recombination technology may be valuable tools for in vivo investigations in toxicopathogenesis. A short review is given on the phenotype of mice with distinct deletions of cytokines and related genes. The application of these mice in pharmacological and toxic...
Topics
- Acute-Phase Proteins
- Animals
- Bone Marrow
- Cytokines
- DNA, Recombinant
- Liver
- Mice
- Mice, Knockout
- Phenotype
- Receptors, Cytokine
- Research Design
- Shock, Septic
- Toxicology