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Article

Investigation of the pattern of diversity of hepatitis C virus in relation to times of transmission.

Journal of viral hepatitis - 1 Jan 1997

Simmonds P, Smith D B

Abstract excerpt

The rate of sequence change of HCV in vivo was used to date the spread of HCV genotype 1b in European, USA and Japanese populations. Silent substitution rates of 0.0011 and 0.0017 substitutions per site per year were observed in the NS5 and E1 regions by sequence comparisons from a cohort of individuals infected from a common source of infection 17 years previously. Mean silent substitution frequencies of 0.169...

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Identifiers

PMID: 9097281
DOI: 10.1111/j.1365-2893.1997.tb00163.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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