Article
A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002
Tanaka Yasuhito, Hanada Kousuke, Mizokami Masashi, Yeo Anthony E T, Shih J Wai-Kuo, Gojobori Takashi, Alter Harvey J
Abstract excerpt
The prevalence of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is considerably lower in the U.S. than in Japan. To elucidate this difference, we determined the time origin of the HCV epidemic in each country by using molecularly clocked long-term serial samples obtained from HCV carriers of genotypes 1a and 1b. The molecular clock estimated that HCV genotype 1 first appeared in Japan in around...
Topics
- Adult
- Evolution, Molecular
- Female
- Follow-Up Studies
- Forecasting
- Genetic Variation
- Genome, Viral
- Genotype
- Hepacivirus
- Hepatitis C
- Humans
- Incidence
- Japan