Article
The global spread of hepatitis C virus 1a and 1b: a phylodynamic and phylogeographic analysis.
PLoS medicine - 1 Dec 2009
Magiorkinis Gkikas, Magiorkinis Emmanouil, Paraskevis Dimitrios, Ho Simon Y W, Shapiro Beth, Pybus Oliver G, Allain Jean-Pierre, Hatzakis Angelos
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa. Previous attempts to estimate the spatiotemporal parameters of the virus, both globally and regionally, have suggested that epidemic HCV transmission began in 1900 and grew steadily until the late...
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