Article
The effects of genotyping errors and interference on estimation of genetic distance.
Human heredity - 1 Jan 2000
Goldstein D R, Zhao H, Speed T P
Abstract excerpt
Analysis of linkage data has typically been carried out assuming genotyping errors are absent. Recent studies have shown, however, that the impact of ignoring genotyping errors can be great, especially in dense marker maps [Buetow, Am J Hum Genet 1991; 49:985-994; Lincoln and Lander, Genomics 1992; 14:604-610]. Because most organisms exhibit positive chiasma interference, we use the chi 2 model [Foss et al.,...
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