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Article

Retinoic acid receptor alpha is required for synchronization of spermatogenic cycles and its absence results in progressive breakdown of the spermatogenic process.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2004

Chung Sanny S W, Sung Wengkong, Wang Xiangyuan, Wolgemuth Debra J

Abstract excerpt

Targeted mutagenesis of the retinoic acid receptor alpha (RAR alpha) gene has revealed its essential role in spermatogenesis. Although cells in all stages of spermatogenesis were detected in RAR alpha(-/-) testes, there was an increase in degenerating pachytene spermatocytes and a temporary developmental arrest in step 8-9 spermatids in the first wave of spermatogenesis, a delay in the onset of the second wave,...

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Identifiers

PMID: 15254909
DOI: 10.1002/dvdy.20083
PMCID: PMC3785309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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