Article
Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17.
Journal of virology - 1 May 1997
Cannon P M, Matthews S, Clark N, Byles E D, Iourin O, Hockley D J, Kingsman S M, Kingsman A J
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) matrix protein, p17, plays important roles in both the early and late stages of the viral life cycle. Using our previously determined solution structure of p17, we have undertaken a rational mutagenesis program aimed at mapping structure-function relationships within the molecule. Amino acids hypothesized to be important for p17 function were mutated and examined...
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