Article
Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium falciparum multidrug resistance gene-1 polymorphisms in the Democratic Republic of Congo and Uganda.
PloS one - 1 Jan 2018
Baraka Vito, Mavoko Hypolite Muhindo, Nabasumba Carolyn, Francis Filbert, Lutumba Pascal, Alifrangis Michael, Van Geertruyden Jean-Pierre
Abstract excerpt
BACKGROUND: The emergence of resistance against artemisinin combination treatment is a major concern for malaria control. ACTs are recommended as the rescue treatment, however, there is limited evidence as to whether treatment and re-treatment with ACTs select for drug-resistant P. falciparum parasites. Thus, the purpose of the present study is to investigate the impact of (re-)treatment using...
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