Article
D2 dopamine receptor A1 allele in Alzheimer disease and aging.
Archives of neurology - 1 Mar 1997
Small G W, Noble E P, Matsuyama S S, Jarvik L F, Komo S, Kaplan A, Ritchie T, Pritchard M L, Saunders A M, Conneally P M, Roses A D, Haines J L, Pericak-Vance M A
Abstract excerpt
BACKGROUND: The apolipoprotein E4 (APOE*4) allele is a major risk factor for the common forms of late-onset Alzheimer disease (AD), but does not account for all the genetic variation in late-onset AD; hence, other genetic markers must be examined. The D2 dopamine receptor (DRD2) A1 allele is associated with abnormal brain function and decreased DRD2s. These receptors are decreased in hippocampus and amygdala in...
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