Article
Association between early-onset alcoholism and the dopamine D2 receptor gene.
American journal of medical genetics - 18 Apr 1997
Kono Y, Yoneda H, Sakai T, Nonomura Y, Inayama Y, Koh J, Sakai J, Inada Y, Imamichi H, Asaba H
Abstract excerpt
We examined the allelic association between the dopamine D2 receptor (DRD2) gene and alcoholism in 100 biologically unrelated Japanese alcoholics and 93 unrelated controls. Genomic DNA was prepared from peripheral white blood cells using the phenol-chloroform method. A 310-bp region surrounding the TaqA site at the DRD2 locus was amplified by polymerase chain reaction (PCR), and the PCR product was incubated with...
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