Article
alpha-adducin may control blood pressure both in rats and humans.
Clinical and experimental pharmacology & physiology. Supplement - 1 Dec 1995
Bianchi G, Tripodi M G, Casari G, Torielli L, Cusi D, Barlassina C, Stella P, Zagato L, Barber B R
Abstract excerpt
1. Previous studies on the pathogenetic mechanisms of hypertension in the Milan hypertensive strain of rat (MHS) showed that a polymorphism within the alpha-adducin gene is responsible for up to 50% of the blood pressure difference between MHS and their MNS normotensive control strain. A case-control study has shown also in humans an association between alpha-adducin locus and hypertension using 4 multiallelic...
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