Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission.

Human molecular genetics - 1 Feb 1997

Murray A, Macpherson J N, Pound M C, Sharrock A, Youings S A, Dennis N R, McKechnie N, Linehan P, Morton N E, Jacobs P A

Abstract excerpt

Factors involved in the stability of trinucleotide repeats during transmission were studied in 139 families in which a full mutation, premutation or intermediate allele at either FRAXA or FRAXE was segregating. The transmission of alleles at FRAXA, FRAXE and four microsatellite loci were recorded for all individuals. Instability within the minimal and common ranges (0-40 repeats for FRAXA, 0-30 repeats for FRAXE)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Fragile X Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haplotypes

Share to Mutation

Share to Pedigree

Share to Recombination, Genetic

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 9063737
DOI: 10.1093/hmg/6.2.173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission.PMID 9063737Read ↗

Stability and haplotype analysis of the FRAXE region.Semantic proximity Read ↗

Paternally transmitted FMR1 alleles are less stable than maternally transmitted alleles in the common and intermediate size range.Semantic proximity Read ↗

Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.Semantic proximity Read ↗

FRAXA and FRAXE: the results of a five year survey.Semantic proximity Read ↗

Studies of FRAXA and FRAXE in women with premature ovarian failure.Semantic proximity Read ↗

Sequence analysis of the fragile X trinucleotide repeat: implications for the origin of the fragile X mutation.Semantic proximity Read ↗

Screening and instability of FMR1 alleles in a prospective sample of 24,449 mother-newborn pairs from the general population.Semantic proximity Read ↗

Transmission of the FRAXA haplotype from three nonpenetrant brothers to their affected grandsons: an update with AGG interspersion analysis.Semantic proximity Read ↗

FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis.Semantic proximity Read ↗

Insert size and flanking haplotype in fragile X and normal populations: possible multiple origins for the fragile X mutation.Semantic proximity Read ↗

Phenotype correlation and intergenerational dynamics of the Friedreich ataxia GAA trinucleotide repeat.Semantic proximity Read ↗

The FRAXA and FRAXE allele repeat size of boys from the Avon Longitudinal Study of Parents and Children (ALSPAC)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.