Insert size and flanking haplotype in fragile X and normal populations: possible multiple origins for the fragile X mutation.

doi:10.1093/hmg/3.3.399

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Article

Insert size and flanking haplotype in fragile X and normal populations: possible multiple origins for the fragile X mutation.

Human molecular genetics - 1 Mar 1994

Macpherson J N, Bullman H, Youings S A, Jacobs P A

Abstract excerpt

A number of recent studies have found non-random association between the fragile X mutation and genotypes for the closest-linked flanking markers, suggesting either a limited number of 'founder' mutations or, alternatively, a predisposing haplotype for the fragile X expansions. Using three micros...

Topics

DNA, Satellite
Female
Fragile X Syndrome
Genetic Markers
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Mutation
Polymorphism, Genetic
Reference Values
Repetitive Sequences, Nucleic Acid

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