Article
Activation of microglial and endothelial cells in the rat brain after treatment with interferon-gamma in vivo.
Glia - 1 Mar 1997
Grau V, Herbst B, van der Meide P H, Steiniger B
Abstract excerpt
Activation of microglial cells occurs during the pathogenesis of various neurologic diseases. However, the mechanisms of activation in vivo are still elusive. We infused adult rats intravenously with interferon-gamma and demonstrated microglial cell activation after three days of treatment. We show for the first time that microglial cells proliferate inside the brain in response to a circulating cytokine....
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