Article
The use and interpretation of commercial APC gene testing for familial adenomatous polyposis.
The New England journal of medicine - 20 Mar 1997
Giardiello F M, Brensinger J D, Petersen G M, Luce M C, Hylind L M, Bacon J A, Booker S V, Parker R D, Hamilton S R
Abstract excerpt
BACKGROUND: The use of commercially available tests for genes linked to familial cancer has aroused concern about the impact of these tests on patients. Familial adenomatous polyposis is an autosomal dominant disease caused by a germ-line mutation of the adenomatous polyposis coli (APC) gene that causes colorectal cancer if prophylactic colectomy is not performed. We evaluated the clinical use of commercial APC...
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