Article
Molecular diagnosis of familial adenomatous polyposis.
The New England journal of medicine - 30 Dec 1993
Powell S M, Petersen G M, Krush A J, Booker S, Jen J, Giardiello F M, Hamilton S R, Vogelstein B, Kinzler K W
Abstract excerpt
BACKGROUND: Familial adenomatous polyposis is an inherited disease characterized by multiple colorectal tumors. The diagnosis has classically been based on the detection of multiple colorectal adenomas. The recent identification of germline mutations of the APC gene in patients with familial aden...
Topics
- Adenomatous Polyposis Coli
- Adenomatous Polyposis Coli Protein
- Adolescent
- Adult
- Aged
- Alleles
- Female
- Genes, APC
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Proteins
- Polymerase Chain Reaction
- Transcription, Genetic