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Article

Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus.

Journal of virology - 1 Jun 1995

Frese M, Kochs G, Meier-Dieter U, Siebler J, Haller O

Abstract excerpt

Thogoto and Dhori viruses are tick-borne orthomyxoviruses infecting humans and livestock in Africa, Asia, and Europe. Here, we show that human MxA protein is an efficient inhibitor of Thogoto virus but is inactive against Dhori virus. When expressed in the cytoplasm of stably transfected cell lines, MxA protein interfered with the accumulation of Thogoto viral RNA and proteins. Likewise, MxA(R645), a mutant MxA...

Topics

Animals
Antiviral Agents
Chlorocebus aethiops
GTP-Binding Proteins
Humans
Mutation
Myxovirus Resistance Proteins
Proteins
Thogotovirus
Vero Cells
Virus Replication

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Identifiers

PMID: 7745744
DOI: 10.1128/JVI.69.6.3904-3909.1995
PMCID: PMC189115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7745744-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus.PMID 7745744Read ↗

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MxA GTPase Blocks Reporter Gene Expression of Reconstituted Thogoto Virus Ribonucleoprotein ComplexesSemantic proximity Read ↗

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Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus.Semantic proximity Read ↗

Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon SignalingSemantic proximity Read ↗

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Mx1 sensitivity: Batken virus is an orthomyxovirus closely related to Dhori virus.Semantic proximity Read ↗

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