Article
Screening for renal carcinoma associated mutations in the von Hippel-Lindau tumor suppressor gene by temperature gradient gel electrophoresis.
Electrophoresis - 1 Jan 1997
Wenzel M, Enczmann J, Uhrberg M, Hernández A, Wiese U, Ackermann R, Schmitz-Draeger B, Ebert T, Wernet P
Abstract excerpt
Renal cell carcinoma is the most common neoplastic disease of the adult kidney and occurs in its sporadic and hereditary form. Approximately 57% of all renal carcinomas of the clear cell type analyzed revealed a mutation in the von Hippel-Lindau disease (VHL) gene. In the present work, temperature gradient gel electrophoresis (TGGE) is presented as a rapid and precise polymerase chain reaction (PCR)-employing...
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