Article
Mutational analysis of the DNA mismatch repair gene hMLH1 in myeloid leukaemias.
British journal of haematology - 1 Sept 1999
Auner H W, Olipitz W, Hoefler G, Bodner C, Konrad D, Crevenna R, Linkesch W, Sill H
Abstract excerpt
Mutations of the DNA mismatch repair (MMR) gene hMLH1 have recently been linked to the development of some hereditary and sporadic cancers which frequently display widespread microsatellite instability (MSI). Conflicting results regarding the extent of MSI in myeloid leukaemias prompted us to perform mutational analysis of all 19 exons of the hMLH1 gene by polymerase chain reaction-single-stranded conformation...
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