Article
Generation of vaccine-primed lymphocytes for the treatment of head and neck cancer.
Head & neck - 1 Mar 2003
Chang Alfred E, Li Qiao, Jiang Guihua, Teknos Theodoros N, Chepeha Douglas B, Bradford Carol R
Abstract excerpt
BACKGROUND: This study was performed to assess the ability of autologous tumor vaccines to induce T-cell reactivity to squamous cell cancers (SCC). METHODS: Irradiated autologous tumor cells admixed with bacillus Calmette-Guérin (BCG) were given intradermally in patients with advanced head and neck cancers. Vaccine-primed lymph node (VPLN) cells were secondarily activated with anti-CD3 mAb and expanded in IL-2...
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