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Article

Genetic testing among high-risk individuals in families with hereditary nonpolyposis colorectal cancer.

British journal of cancer - 23 Feb 2004

Ponz de Leon M, Benatti P, Di Gregorio C, Pedroni M, Losi L, Genuardi M, Viel A, Fornasarig M, Lucci-Cordisco E, Anti M, Ponti G, Borghi F, Lamberti I, Roncucci L

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with constitutional mutations in a class of genes involved in DNA mismatch repair. We identified 32 kindreds, with germline mutations in one of three genes hMSH2, hMLH1 or hMSH6. In this study, we purposed to evaluate how...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Base Pair Mismatch

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonoscopy

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Germ-Line Mutation

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 14970868
DOI: 10.1038/sj.bjc.6601529
PMCID: PMC2410159

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14970868-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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