Article
Interethnic polymorphism of EWS intron 6: genome plasticity mediated by Alu retroposition and recombination.
Human genetics - 1 Mar 1997
Zucman-Rossi J, Batzer M A, Stoneking M, Delattre O, Thomas G
Abstract excerpt
The EWS gene has been identified as being systematically translocated in Ewing's sarcoma. In order to ascertain the basis of a marked interethnic difference in the incidence of Ewing's sarcoma, intron 6 of EWS, which is located near the translocation breakpoint region (EWSR1), was characterized. Sequence analysis of the entire intron 6 region revealed a very high density of Alu elements. Most of these Alu...
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