Article
Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study.
Pediatric blood & cancer - 15 Jul 2012
DuBois Steven G, Goldsby Robert, Segal Mark, Woo Jonathan, Copren Kirsten, Kane John P, Pullinger Clive R, Matthay Katherine K, Witte John, Lessnick Stephen L, Robison Leslie L, Bhatia Smita, Strong Louise C
Abstract excerpt
BACKGROUND: Ewing sarcoma is a malignant bone tumor characterized by a high frequency of somatic EWSR1 translocations. Ewing sarcoma is less common in people of African or African-American ancestry, suggesting a genetic etiology. PROCEDURE: Germline DNA from white patients with Ewing sarcoma (n = 135), white controls with Wilms tumor (n = 200), and African-American controls (n = 285) was genotyped at 21 SNPs in...
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