Article
Mutants in the CtpA copper transporting P-type ATPase reduce virulence of Listeria monocytogenes.
Microbial pathogenesis - 1 Feb 1997
Francis M S, Thomas C J
Abstract excerpt
The CtpA protein from pathogenic Listeria monocytogenes, is a P-type adenosine triphosphatase involved in copper homeostasis. To establish a role in pathogenicity for CtpA, a mutant strain was constructed by insertion of an antibiotic resistance cartridge into the ctpA gene. This mutant was then compared to the wild-type in tissue culture invasion assays and mouse infection studies. Mutants in CtpA, were...
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