Article
A putative P-type ATPase required for virulence and resistance to haem toxicity in Listeria monocytogenes.
PloS one - 1 Jan 2012
McLaughlin Heather P, Xiao Qiaobin, Rea Rosemarie B, Pi Hualiang, Casey Pat G, Darby Trevor, Charbit Alain, Sleator Roy D, Joyce Susan A, Cowart Richard E, Hill Colin, Klebba Phillip E, Gahan Cormac G M
Abstract excerpt
Regulation of iron homeostasis in many pathogens is principally mediated by the ferric uptake regulator, Fur. Since acquisition of iron from the host is essential for the intracellular pathogen Listeria monocytogenes, we predicted the existence of Fur-regulated systems that support infection. We examined the contribution of nine Fur-regulated loci to the pathogenicity of L. monocytogenes in a murine model of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.