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GLUCOCORTICOID AND MINERALOCORTICOID RECEPTORS: Biology and Clinical Relevance

1 Feb 1997

Abstract excerpt

Mineralocorticoid and glucocorticoid receptors act as homodimers via canonical pentadecamer hormone response elements to regulate transcription. Glucocorticoid, but as yet not mineralocorticoid, receptors have been shown also to modulate AP-1- and NF kappa B-induced transcription by direct protein-protein interactions. The role of 11 beta-hydroxysteroid dehydrogenase in conferring aldosterone specificity on...

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Identifiers

PMID: 9046958
DOI: 10.1146/annurev.med.48.1.231

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