Article
L-histidinol selectively modulates daunomycin toxicity in normal and tumorigenic kidney epithelial cells.
Anticancer research - 1 Jan 2000
Warrington R C, Fang W D, Zhang L, Shieh M, Saier M H
Abstract excerpt
L-Histidinol protects normal cells from anticancer drugs while enhancing the ability of these agents to eradicate tumor cells. We now report that this attribute, previously documented in normal and tumor cells of fibroblastic or myeloid origin, extends to epithelial lines. Clonogenic cell survival assays showed that L-histidinol protected the normal Madin-Darby canine kidney (MDCK) epithelial cell line from...
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