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JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 Axis

8 May 2025

Abstract excerpt

JS-K is a precursor drug of nitric oxide (NO) and inhibits tumor growth through various mechanisms. Ferroptosis, a form of cell death closely related to lipid peroxidation, is increasingly being recognized for its role in cancer biology. However, the relevance of ferroptosis in the anti-tumor effects of JS-K is yet to be defined. The cytotoxic effects of erastin and JS-K were evaluated in various renal cell...

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PMID: 40341677
DOI: 10.1038/s41598-025-97887-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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