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Molecular signatures of disulfidptosis: interplay with programmed cell death pathways and therapeutic implications in oncology

2 Jun 2025

Abstract excerpt

Disulfidptosis represents a newly identified form of regulated cell death (RCD) distinct from other well-established RCD pathways. It occurs during periods of glucose starvation, specifically when intracellular NADPH is rapidly depleted and the expression of Solute Carrier Family 7 Member 11 (SLC7A11) is highly upregulated. Cancer cells utilize SLC7A11 to import cystine from the extracellular environment, and...

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PMID: 40457177
DOI: 10.1186/s11658-025-00743-5

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