Mutagenesis of charged residues in a conserved sequence in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

doi:10.1042/bj3210609

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Article

Mutagenesis of charged residues in a conserved sequence in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

The Biochemical journal - 1 Feb 1997

Bertrand L, Vertommen D, Feytmans E, Di Pietro A, Rider M H, Hue L

Abstract excerpt

Arg-136, Glu-137, Arg-138 and Arg-139 are conserved in all sequences of the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Their role was studied by site-directed mutagenesis. All the mutations had little, if any, effect on fructose-2,6-bisphosphatase activity. Mutations...

Topics

Adenosine Triphosphate
Amino Acid Sequence
Animals
Circular Dichroism
Conserved Sequence
Fluorescence
Fructose-Bisphosphatase
Fructosephosphates
Guanidine
Guanidines
Isoenzymes
Kinetics
Models, Chemical
Molecular Sequence Data
Mutagenesis, Site-Directed

Source

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Identifiers

PMID: 9032444
DOI: 10.1042/bj3210609
PMCID: PMC1218113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9032444-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutation

Oligodeoxyribonucleotides

Phosphofructokinase-1