In vitro evidence that the reduction in mesencephalic dopaminergic neurons in the weaver heterozygote is not due to a failure in target cell interaction.

doi:10.1007/pl00005679

Back to search

Article

In vitro evidence that the reduction in mesencephalic dopaminergic neurons in the weaver heterozygote is not due to a failure in target cell interaction.

Experimental brain research - 1 Jun 1997

Won L, Ghetti B, Heller B, Heller A

Abstract excerpt

The murine weaver (wv) mutation is characterized by a genetically determined loss of several neuronal populations, which include the nigrostriatal dopaminergic neurons. Animals homozygous for the wv gene exhibit marked deficits in dopaminergic morphological and neurochemical parameters. The wv ge...

Topics

Animals
Dopamine
Female
Genotype
Heterozygote
Immunohistochemistry
Mesencephalon
Mice
Mice, Neurologic Mutants
Neostriatum
Neurons
Pregnancy
Tyrosine 3-Monooxygenase

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.