Article
Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse.
Journal of neural transmission. General section - 1 Jan 1994
Stotz E H, Palacios J M, Landwehrmeyer B, Norton J, Ghetti B, Simon J R, Triarhou L C
Abstract excerpt
In the striatum of the homozygous weaver mutant mouse (wv/wv), dopamine content, uptake and tyrosine hydroxylase activity are decreased compared to wild-type (+/+) mice. In mice heterozygous for the weaver gene (wv/+), these dopaminergic parameters exhibit only minor reductions compared to +/+ mice. The wv/wv striatum has recently been shown to have an increase in serotonin content. In the present study, the...
Topics
- Animals
- Autoradiography
- Citalopram
- Dopamine
- Genotype
- In Vitro Techniques
- Kinetics
- Mazindol
- Mice
- Mice, Neurologic Mutants
- Neostriatum