Post-transcriptional regulation of tyrosine hydroxylase gene expression by oxygen in PC12 cells.

doi:10.1038/ki.1997.84

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Article

Post-transcriptional regulation of tyrosine hydroxylase gene expression by oxygen in PC12 cells.

Kidney international - 1 Feb 1997

Czyzyk-Krzeska M F, Paulding W R, Beresh J E, Kroll S L

Abstract excerpt

Reduced oxygen tension (hypoxia) leads to increased stability of mRNA for tyrosine hydroxylase (TH), the rate limiting enzyme in biosynthesis of catecholamine neurotransmitters. Hypoxia increases the half life of TH mRNA from 10 to 30 hours. The increased stability of TH mRNA during hypoxia resul...

Topics

Animals
Base Sequence
Binding Sites
Cell Hypoxia
Gene Expression Regulation, Enzymologic
Mutation
Oxygen
PC12 Cells
Protein Binding
RNA, Messenger
RNA-Binding Proteins
Rats
Tyrosine 3-Monooxygenase

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