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Article

Transgenic mouse models in studies of skeletal disorders.

The Journal of rheumatology. Supplement - 1 Feb 1995

Jacenko O, Olsen B R

Abstract excerpt

Studies of mutations in mice and humans are identifying molecular defects in a number of osteochondrodysplasias. Disruption of collagen IX function in mice using 3 transgenic approaches causes a degenerative joint disease resembling osteoarthritis (OA). Mapping of a multiple epiphyseal dysplasia locus to the chromosomal region of COL9A2 suggests that certain heritable forms of OA in humans are also associated...

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PMID: 7752133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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