Article
Transgenic mouse models in studies of skeletal disorders.
The Journal of rheumatology. Supplement - 1 Feb 1995
Jacenko O, Olsen B R
Abstract excerpt
Studies of mutations in mice and humans are identifying molecular defects in a number of osteochondrodysplasias. Disruption of collagen IX function in mice using 3 transgenic approaches causes a degenerative joint disease resembling osteoarthritis (OA). Mapping of a multiple epiphyseal dysplasia...
Topics
- Animals
- Chromosome Mapping
- Collagen
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Osteoarthritis
- Osteochondrodysplasias