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Article

Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells.

Biomolecules - 19 Jun 2025

Chen Oleg, Vovk Olena, Polishchuk Nikita, Mayevska Oksana, Shuvayeva Galyna, Demir Melike, Lukiyanchuk Vasyl, Kunz-Schughart Leoni A, Dubrovska Anna, Stasyk Oleh

Abstract excerpt

Purpose: The development of acquired resistance to arginine deprivation therapy (ADT) is a major barrier to its efficacy. This study aimed to elucidate the possible mechanisms underlying the resistance to ADT. Methods: We applied repeated ADT and established a subline SAS-R9 of the human head and neck squamous cell carcinoma (HNSCC) cells semi-resistant to arginine (Arg) deprivation in vitro. This subline was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Breaks, Double-Stranded

Share to Epithelial-Mesenchymal Transition

Share to Head and Neck Neoplasms

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Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 40563540
DOI: 10.3390/biom15060900
PMCID: PMC12190576

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