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Article

Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins

1 Feb 1997

Abstract excerpt

The antitumor agent cis-diamminedichloroplatinum(II) (cisplatin) introduces cytotoxic DNA damage predominantly in the form of intrastrand crosslinks between adjacent purines. Binding assays using a series of duplex oligonucleotides containing a single 1,2 diguanyl intrastrand crosslink indicate that human cell extracts contain factors that preferentially recognise this type of damage when the complementary strand...

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Identifiers

PMID: 9016586
DOI: 10.1093/nar/25.3.491

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