Article
Ki-ras mutations in adenomas: a characteristic of cancer-bearing colorectal mucosa.
The Journal of pathology - 1 Dec 1996
Morris R G, Curtis L J, Romanowski P, Hardcastle J D, Jenkins D A, Robinson M, Wyllie A H, Bird C C
Abstract excerpt
Activating mutations in the Ki-ras2 oncogene are frequently observed in sporadic colorectal adenomas and their incidence is reported to rise in large and tubulovillous adenomas to values close to those in carcinomas. This study shows that this property is a feature of adenomas growing in large bowel that has already demonstrated its propensity to engender malignant tumours: i.e., bowel in which there is a...
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