Ki-ras mutations in adenomas: a characteristic of cancer-bearing colorectal mucosa.

doi:10.1002/(SICI)1096-9896(199612)180:4<357::AID-PATH710>3.0.CO;2-D

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Article

Ki-ras mutations in adenomas: a characteristic of cancer-bearing colorectal mucosa.

The Journal of pathology - 1 Dec 1996

Morris R G, Curtis L J, Romanowski P, Hardcastle J D, Jenkins D A, Robinson M, Wyllie A H, Bird C C

Abstract excerpt

Activating mutations in the Ki-ras2 oncogene are frequently observed in sporadic colorectal adenomas and their incidence is reported to rise in large and tubulovillous adenomas to values close to those in carcinomas. This study shows that this property is a feature of adenomas growing in large bo...

Topics

Adenoma
Age Factors
Aged
Aged, 80 and over
Colorectal Neoplasms
Disease Progression
Genes, APC
Genes, ras
Humans
Middle Aged
Mutation
Risk Factors

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